Our lab works on both fundamental biology and drug discovery. We study protein trafficking in the early secretory pathway, specifically the export of native proteins from dedicated areas of the ER called ER exit sites (ERES). We use ERES modulation to understand the organisational changes that ERES undergo which allow them to handle different rates of protein secretion. To complement this, we work on the development of pharmacological inhibitors of ERES to better understand the cellular context of aberrant secretion events observed in certain disease states. 

We specialise in the use of cutting-edge microscopy techniques to study protein trafficking and homeostatic processes in mammalian cells. Our research is complemented by interdisciplinary collaborations, working with collaborators in advanced bioimage analysis, chemistry and chemical biology.